Facilities Cores

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Animal Models Facilities Core

Facilities Core

Genomics and Imaging Facilities Core

Integrative Health Sciences Facilities Core

Facilities Cores

The four state-of-the-art Facilities Cores provide Center members with the technologies, expertise and services that are not available from other sources at MIT. The following Facilities Cores reflect the new research directions of the Center:

Animal Models
Facilities Core
Director: Prof. James Fox

The Animal Models Facilities Core

A substantial fraction of the research carried out in the CEHS involves the use of animal models of human disease. To meet this need, the Animal Models Facilities Core, directed by Prof. James Fox, provides numerous services to Center members, including overseeing husbandry for all the animals used by CEHS members (rats and mice), development of transgenic knock-out and knock-down animal models, histopathology, advanced tissue imaging, DNA sequencing, real-time PCR and other technologies related to cell and molecular biology, as well as the services of board certified pathologists. The Core is comprised of the facilities, services and expertise of the Division of Comparative Medicine at MIT.


Facilities Core
Director: Dr. J. Pete Wishnok
    Co-Director: Dr. Koli Taghizadeh

The Bioanalytical Facilities Core

This Facilities Core is co-directed by Drs. Wishnok and Taghizadeh.  The Bioanalytical Facilities Core is a central resource in analytical chemistry, separation science, and proteomics for Center members and provides research participants with analytical expertise, training, and access to state-of-the-art instrumentation. This Facilities Core is home to a world-class chromatography and mass spectrometry facility, including an accelerator mass spectrometer, that provides CEHS members with state-of-the-art chemical molecular separation, identification, and quantification capabilities. The Bioanalytical Facilities Core is comprised of the Bioanalytical Laboratory in Building 16 (room 720) and the Biological Engineering Mass Spectrometry Facility in Building 56 (room 747). Training and assistance is provided by the Directors.


The Genomics and Imaging
Facilities Core
 Co-Director: Dr. Stuart Levine
Co-Director: Dr. Robert Croy  

The Genomics and Imaging Facilities Core

The goal of this Facilities Core, formerly led by Dr. Rebecca Fry, is to provide state-of-the-art tools, services, and expertise in the areas of genomics and bioinformatics to Center members. This Facilities Core provides access to a variety of different genomics platforms (i.e., Affymetrix GeneChips, Agilent arrays, oligonucleotide and cDNA arrays, and antibody arrays) and to the bioinformatic tools and expertise required to analyze genomic scale data. This Facilities Core provides training and expertise to the members of all CEHS labs using this experimental approach. 


Integrative Health Sciences
Facilities Core
  Co-Director: Prof. Peter Dedon 
     Co-Director: Prof. Bevin Engelward

Co-Director: Prof. John Essigmann 



Integrative Health Sciences Facilities Core (IHSFC)

The MIT CRC has merged with several other clinical research entities in the Boston/Cambridge area to form the so-called Harvard Catalyst, essentially a Clinical and Translational Science Center (CTSC; http://catalyst.harvard.edu/home.html); since then the MIT CRC has also become known as the MIT CTSC.  Center researchers now have access to the many resources of the Harvard Catalyst, including pilot project funding, and access to clinical studies and collaborations with clinical investigators.  This Facilities Core thus plays critical roles in the Center both in the potential for research collaboration with other Center members and in facilitating translational research in the CEHS.

The IHSFC provides Center members with the resources of the MIT CTSC.  The goals of the MIT CTSC parallel those of the CEHS IHSFC: (i) Provide scientists and physicians with a facility to perform clinical investigation; (ii) Provide assistance in the designing clinical protocols and epidemiological survey tools; (iii) Provide tools to assist in the protocol submission/approval process; (iv) Provide nursing staff to perform clinical duties in the context of research protocols; (v) Provide biostatistics expertise in data analysis.