2006-2007 Pilot Project Recipients


The Role of Vascular Endothelian Cell Damage in Tissue Response to Low-Dose Radiation

The overall objective of this study is to investigate the role that damage the vascular endothelium plays in the molecular and cellular signaling events in tissue following exposure to low doeses of radiation

  • Jeffrey Coderre
    Associate Professor, Nuclear Science and Engineering

Transcriptional Networks Affected by Agents that Suppress Toxicity and Carcinogens by Aflatoxin B1: Implications for Interventions Against Liver Cancer

This project is to develop a rat model system to investigate the mechanistic underpinning of the protective effects of metabolic modulators in AFB1-induced liver tumorigenesis, as well as to examine how two agents known to suppress the toxicity and carcinogenicity of AFB1 influence the transcriptional and metabolic networks of the rat.

  • John Essigmann
    Professor, Biological Engineering

Microfluidic Investigations of Motility of Environmental Pathogens: Helicobacter Pylori

This project will assess the suitability of microfluidics to study the dynamics of environmental pathogens by exploring several aspects regarding the motility and response to external cues of H. pylori.

  • Roman Stocker
    Assistant Professor, Civil and Environmental Engineering

Developing a Strategy for Interrogating the Metabolic State of Hepatocyte Cultures

This project will develop a strategy for interrogating the metabolic state of hepatocyte cultures.

  • Steven Tannenbaum
    Professor, Biological Engineering

The Cell is a Molecular Machine (Continued)

Proposed to create several video clips of the CEHS faculty explaining their research for the MIT Museum Exhibit: “The Cell is a Molecular Machine”.

  • Kathy Vandiver
    Director, Community Outreach & Education Program, Center for Environmental Health Sciences

A High-Throughput Automated Microscopy-Based RNAi Screen for Modifiers of the DNA Damage Response

This project proposes to use an RNAi-based screen to identify novel protein kinases or phosphatases that modulate DNA damage pathways activated in response to exposure to ionizing radiation.

  • Michael Yaffe
    Associate Professor, Biology

Design and Construction of a Long-Term, Low Dose-Rate Mammalian Cell Irradiator

The ultimate goal of this project is to examine the effects of radiation on a variety of molecular, cellular and animal endpoints from exposures mimicking environmental conditions.

  • Jacquelyn Yanch
    Professor, Nuclear Science & Engineering and Biological Engineering