Basic Science Applications

The Health Impacts of Use of Leaded Aviation Gasoline

This study aims to quantify population exposire to airborne lead associated with use of leaded avaiation gasoline. The resultant children's IQ loss incidence and its impact on U.S. economy will be estimated.

• Steven Barrett
  Assistant Professor, Aeronautics and Astronautics
• Noelle Selin
  Assistant Professor, Engineering System and Atmospheric Chemistry
• Steve Hung Lam Yim
  Research Scientist*, Aeronautics and Astronautics

Development of Application of the RADR/GptΔ Mouse Model: Convergent Technologies for Revealing the Mutagenic Potential of Inflammation

The proposed study describes an approach for specifically querying the HR susceptibility of somatic stem cells in the colon. The proposed studies will both provide new mechanistic insights into inflammation-induced cancer, while at the same time paving the way for the application of this mouse model to additional problems.

• Bevin P. Engelward
  Associate Professor, Biological Engineering
• Gerald N. Wogan
  Emeritus Professor, Biological Engineering

Investigating the Differential Environmental Stability of Influenza Virus Particles: Does Variation in Lipid Content Explain Host Shift Events?

This pilot project proposes to explore the role of the viral lipid membrane in viral environmental stability, with particulat focus on how stability may be critical in defining the ecology and evolution of influenza infection in natural reservoirs and potential transmission to novel hosts, such as humans.

• Jonathan Runstadler
  Assistant Professor, Biological Engineering and Division of Compartive Medicine
• Wendy Puryear
  Research Scientist*, Division of Comparative Medicine

Translational Applications

Laboratory Characterization of the Composition and Variability of Solid Biofuel Combustion Emissions

The goal of this proposed work is to better understand the emissions from solid biofuel combustion, by the detailed examination of both the composition and the variability of emissions under a given set of combustion conditions (as a function of fuel type, cookstove design, and other key operational parameters).

• Jesse Kroll
  Associate Professor, Civil and Enviromental Engineering and Chemical Engineering
• Eben Cross
  Research Scientist, Civil and Environmental Engineering

Characterizing oxidative DNA damage and repair in Plasmodium falciparum

The goal of this proposal is to initiate a systematic analysis of the parasite-based mechanisms contributing to this important human health problem.

• Jacquin C. Niles
  Assistant Professor, Biological Engineering
• Bogdan Fedeles
  Senior Postdoctoral Associate, Biological Engineering

Nickel Allergy and Proinflammatory Proteins

The goal of this pilot research initiative is to evaluate a putative role for the proinflammatory proteins calprotectin (CP, S100A8/S100A9) and psoriasin (S100A7) in contact hypersensitivity to nickel, a metal ion that is a component of many consumer products and causes skin allergy in humans.

• Elizabeth Nolan
  Assistant Professor, Chemistry