The MIT Center for Environmental Health Sciences, through support from the NIH-NIEHS Center Grant P30-ES002109, has awarded two basic science and one translational pilot projects with a start date of August 1, 2017 from the May 2017 pilot project call released this year.
The two funded basic science applications are:
(1) Heather Kulik
Assistant Professor, Chemical Engineering
“Quantum Mechanical Contribution to Methyltransferase Inhibition”
In order to address the critical goal of the NIEHS mission to identify and understand fundamental shared mechanisms of epigenetic changes underlying such a broad range of diseases, a more fundamental understanding of toxic metal influence on DNA MTase function is essential to facilitate development of preventative strategies.
(2) Matthew Shoulders
Assistant Professor, Chemistry
“Mechanisms to Zinc-Mediated Sensitivity to Cadmium Exposure”
This proposal outlines pilot studies to define how insufficiency of the essential nutrient Zn(II) modulates the toxicity and uptake of the environmental toxin Cd(II).
The one funded translational application is:
(1) Hadley Sikes
Associate Professor, Chemical Engineering
“Clinical Validation of Hybridization-based Epigenotyping”
The proposed work would represent the first clinical validation study of a hybridization-based epigenotyping assay. The work described herein promotes and enables Goal 1 of NIEHS’ strategic plan, i.e., identifying and understanding the role of epigenetic changes in complex pathologies order to develop prevention and intervention strategies, and it aligns with CEHS’s prioritization of human application.