Single-cell Analysis of Transcriptional and Translational Regulation of Genes Essential for DNA Damage Response
This project is to understand how eukaryotes respond to DNA damage via transcriptional and translational regulation.
- Mark Bathe
Assistant Professor, Biological Engineering
Zebrafish – a Model to Study the Live Mucosa
This project will aim to understand the molecules and mechanisms involved in cell-mucus interactions and study live mucosal pathomechanisms with transgenic zebrafish that express fluorescent mucins.
- Katharina Ribbeck
Assistant Professor, Biological Engineering
Interrogating the Intersection of DNA damage pathways and Metabolism in the Replication Stress Response using Dynamic Molecular Combing
The goal of this project is to identify genes that are required to stabilize DNA replication under hyperreplicative conditions as we expect mutations in the human homologues of these genes to be predisposed to environmental – and/or oncogenes induced carcinogenesis as well as potentially good chemotherapy targets.
- Michael Yaffe
Professor, Biology/Biological Engineering/Koch Institutue